Research Article
Evaluating Giftii Biopesticides Containing Glucosinolates and Hydrolysis Phenolic Compounds for Wheat Leaf Blotch Disease Management
Tsigehana Yewste Mamo*
Issue:
Volume 9, Issue 3, September 2024
Pages:
48-52
Received:
22 May 2024
Accepted:
19 June 2024
Published:
15 August 2024
Abstract: The efficacy of Giftii biopesticide as a substitute fungicide for managing Septoria tritici blotch and enhancing wheat yield was evaluated through comprehensive field trials conducted at multiple locations. The study employed Analysis of Variance (ANOVA) to assess differences among treatments in terms of yield and Area under Disease Progress Curve (AUDPC). The results indicated significant differences (P < 0.05) among the treatments. The trials revealed notable variations in AUDPC across different application rates of Giftii biopesticide. Control plots, which received no treatment, exhibited the highest disease severity with an AUDPC of 1499.17% in days. In contrast, plots treated with Giftii at a rate of 0.75 liters per hectare showed the lowest disease severity, with an AUDPC of 1361.83% in days. These findings demonstrate a substantial reduction in disease spread when Giftii biopesticide was applied, compared to the untreated control plots. In terms of yield, the data showed significant differences among the treatments. The highest mean yield was recorded for the 0.75 liters per hectare application rate of Giftii, producing 4.3 tons per hectare. This was a marked improvement compared to the control treatment, which yielded only 2.7 tons per hectare. Statistical analysis further confirmed a significant difference between the control plots and those treated with 0.5 liters per hectare of Giftii biopesticide. These findings underscore the potential of Giftii biopesticide as an effective fungicide for managing Septoria tritici blotch and improving wheat yields. The significant reduction in disease severity and the corresponding increase in yield with Giftii application suggest it could be a viable alternative to conventional fungicides. The study highlights Giftii's efficacy and supports its consideration for broader use in wheat production to enhance crop health and productivity.
Abstract: The efficacy of Giftii biopesticide as a substitute fungicide for managing Septoria tritici blotch and enhancing wheat yield was evaluated through comprehensive field trials conducted at multiple locations. The study employed Analysis of Variance (ANOVA) to assess differences among treatments in terms of yield and Area under Disease Progress Curve ...
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Research Article
Evaluation of Antioxidant and Anti-inflammatory Activities of a Medicinal Plant Recipe from Burkina Faso
Issue:
Volume 9, Issue 3, September 2024
Pages:
53-62
Received:
26 July 2024
Accepted:
22 August 2024
Published:
6 September 2024
Abstract: Background: Oxidative stress and chronic inflammation are crucial factors in the development of various diseases, such as hepatitis and cancer. In the case of hepatitis, persistent inflammation of the liver contributes to cellular damage and progression to more severe stages of the disease. Objective: The aim of this study is to evaluate the antioxidant and anti-inflammatory activity of a recipe, Hepatib tiben, traditionally used in the treatment of viral hepatitis B, and often associated with Momordica charantia in the treatment of liver cancer in Burkina Faso. Material and Methods: The recipe and associated plants were infused, macerated and the yields were evaluated and being freeze-dried. The extracts obtained were used to determine the total content of phenolic and flavonoid compounds by measuring the antioxidant activity through the FRAP, DPPH and ABTS methods and then the evaluation of the anti-inflammatory properties by inhibition of 15-LOX and COX 1 & 2. Results: The aqueous infusion of Hepatib tiben had the best yield, the highest content of phenolic compounds and flavonoids, an antioxidant activity comparable to that of Rutin, by the FRAP method, DPPH and ABTS method. But the best antioxidant activity by FRAP method was observed with the DCM fraction. It is on the other hand the hydroalcoholic extract which had the best anti-inflammatory activity by the inhibition of the 15-LOX. Both Aqueous and Hydroalcoholic Extracts inhibited COX 1 & 2. Momortica charantia had high phenolic content and significant antioxidant activity by FRAP, DPPH and ABTS methods. Conclusion: These observations suggest that the recipe of traditional medicinal plants used in Burkina Faso could be beneficial in the treatment of inflammatory conditions and oxidative stress. Further studies are needed to identify the active compounds responsible for these activities and to assess their safety and clinical effectiveness.
Abstract: Background: Oxidative stress and chronic inflammation are crucial factors in the development of various diseases, such as hepatitis and cancer. In the case of hepatitis, persistent inflammation of the liver contributes to cellular damage and progression to more severe stages of the disease. Objective: The aim of this study is to evaluate the antiox...
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Review Article
DNA Damage, Transposable Element Expression and Their Associated Factors in Aging
Temesgen Mitiku Yeshanew*,
Betelhem Abebe begashew,
Nega Birhane,
Birhan Getie
Issue:
Volume 9, Issue 3, September 2024
Pages:
63-76
Received:
3 October 2024
Accepted:
25 October 2024
Published:
29 November 2024
Abstract: Aging is a spontaneous and permanent physiological process that leads to declines in tissue and cell functions, along with an increased risk of developing various age-related diseases. The primary driving force associated with aging is the accumulation of damaged genetic material in the cell, such as DNA. DNA damage can be caused by endogenous and exogenous factors, which leads to genome instability, mitochondrial dysfunction, epigenetic modifications, and proteostatic disturb. Another driving force associated with aging is the disruption of cellular metabolism. This disruption is closely linked to alterations in the role of metabolic pathways, including insulin/IGF-1 and mTOR, which regulate crucial cellular processes like cell growth, cell proliferation, and apoptosis. The activation of the insulin/IGF-1 signaling pathway highly promotes cell growth and proliferation, while also inhibits autophagy and increasing ROS production. This ultimately leads to accelerated aging. Another crucial signaling pathway is the mTOR signaling pathway. It is responsible for detecting nutrient availability and controlling cell growth and metabolism. The dysregulation of mTOR function can lead to the development of neurodegenerative diseases, which are characterized by the aggregation of protein. Activation of transposable elements is the other driving force of aging, caused by changes in DNA methylation and the loss of heterochromatin. As a result, this leads to DNA damage, genomic instability, and inflammation. The aim of this review is to elucidate the consequence of DNA damage and other associated factors drive aging.
Abstract: Aging is a spontaneous and permanent physiological process that leads to declines in tissue and cell functions, along with an increased risk of developing various age-related diseases. The primary driving force associated with aging is the accumulation of damaged genetic material in the cell, such as DNA. DNA damage can be caused by endogenous and ...
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