Background: Oxidative stress and chronic inflammation are crucial factors in the development of various diseases, such as hepatitis and cancer. In the case of hepatitis, persistent inflammation of the liver contributes to cellular damage and progression to more severe stages of the disease. Objective: The aim of this study is to evaluate the antioxidant and anti-inflammatory activity of a recipe, Hepatib tiben, traditionally used in the treatment of viral hepatitis B, and often associated with Momordica charantia in the treatment of liver cancer in Burkina Faso. Material and Methods: The recipe and associated plants were infused, macerated and the yields were evaluated and being freeze-dried. The extracts obtained were used to determine the total content of phenolic and flavonoid compounds by measuring the antioxidant activity through the FRAP, DPPH and ABTS methods and then the evaluation of the anti-inflammatory properties by inhibition of 15-LOX and COX 1 & 2. Results: The aqueous infusion of Hepatib tiben had the best yield, the highest content of phenolic compounds and flavonoids, an antioxidant activity comparable to that of Rutin, by the FRAP method, DPPH and ABTS method. But the best antioxidant activity by FRAP method was observed with the DCM fraction. It is on the other hand the hydroalcoholic extract which had the best anti-inflammatory activity by the inhibition of the 15-LOX. Both Aqueous and Hydroalcoholic Extracts inhibited COX 1 & 2. Momortica charantia had high phenolic content and significant antioxidant activity by FRAP, DPPH and ABTS methods. Conclusion: These observations suggest that the recipe of traditional medicinal plants used in Burkina Faso could be beneficial in the treatment of inflammatory conditions and oxidative stress. Further studies are needed to identify the active compounds responsible for these activities and to assess their safety and clinical effectiveness.
| Published in | Biochemistry and Molecular Biology (Volume 9, Issue 3) |
| DOI | 10.11648/j.bmb.20240903.12 |
| Page(s) | 53-62 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Anti-inflammatory, Antioxidant, Recipe, Momordica charantia, Cancer, Hepatitis B
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APA Style
Zongo, P. F. I., Bayala, B., Zongo, L., Yonli, A., Compaore, J. M., et al. (2024). Evaluation of Antioxidant and Anti-inflammatory Activities of a Medicinal Plant Recipe from Burkina Faso. Biochemistry and Molecular Biology, 9(3), 53-62. https://doi.org/10.11648/j.bmb.20240903.12
ACS Style
Zongo, P. F. I.; Bayala, B.; Zongo, L.; Yonli, A.; Compaore, J. M., et al. Evaluation of Antioxidant and Anti-inflammatory Activities of a Medicinal Plant Recipe from Burkina Faso. Biochem. Mol. Biol. 2024, 9(3), 53-62. doi: 10.11648/j.bmb.20240903.12
AMA Style
Zongo PFI, Bayala B, Zongo L, Yonli A, Compaore JM, et al. Evaluation of Antioxidant and Anti-inflammatory Activities of a Medicinal Plant Recipe from Burkina Faso. Biochem Mol Biol. 2024;9(3):53-62. doi: 10.11648/j.bmb.20240903.12
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Download@article{10.11648/j.bmb.20240903.12,
author = {Pengdwendé Fabienne Ingrid Zongo and Bagora Bayala and Luc Zongo and Albert Yonli and Jean Marie Compaore and Jacques Simpore},
title = {Evaluation of Antioxidant and Anti-inflammatory Activities of a Medicinal Plant Recipe from Burkina Faso
},
journal = {Biochemistry and Molecular Biology},
volume = {9},
number = {3},
pages = {53-62},
doi = {10.11648/j.bmb.20240903.12},
url = {https://doi.org/10.11648/j.bmb.20240903.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bmb.20240903.12},
abstract = {Background: Oxidative stress and chronic inflammation are crucial factors in the development of various diseases, such as hepatitis and cancer. In the case of hepatitis, persistent inflammation of the liver contributes to cellular damage and progression to more severe stages of the disease. Objective: The aim of this study is to evaluate the antioxidant and anti-inflammatory activity of a recipe, Hepatib tiben, traditionally used in the treatment of viral hepatitis B, and often associated with Momordica charantia in the treatment of liver cancer in Burkina Faso. Material and Methods: The recipe and associated plants were infused, macerated and the yields were evaluated and being freeze-dried. The extracts obtained were used to determine the total content of phenolic and flavonoid compounds by measuring the antioxidant activity through the FRAP, DPPH and ABTS methods and then the evaluation of the anti-inflammatory properties by inhibition of 15-LOX and COX 1 & 2. Results: The aqueous infusion of Hepatib tiben had the best yield, the highest content of phenolic compounds and flavonoids, an antioxidant activity comparable to that of Rutin, by the FRAP method, DPPH and ABTS method. But the best antioxidant activity by FRAP method was observed with the DCM fraction. It is on the other hand the hydroalcoholic extract which had the best anti-inflammatory activity by the inhibition of the 15-LOX. Both Aqueous and Hydroalcoholic Extracts inhibited COX 1 & 2. Momortica charantia had high phenolic content and significant antioxidant activity by FRAP, DPPH and ABTS methods. Conclusion: These observations suggest that the recipe of traditional medicinal plants used in Burkina Faso could be beneficial in the treatment of inflammatory conditions and oxidative stress. Further studies are needed to identify the active compounds responsible for these activities and to assess their safety and clinical effectiveness.
},
year = {2024}
}
TY - JOUR T1 - Evaluation of Antioxidant and Anti-inflammatory Activities of a Medicinal Plant Recipe from Burkina Faso AU - Pengdwendé Fabienne Ingrid Zongo AU - Bagora Bayala AU - Luc Zongo AU - Albert Yonli AU - Jean Marie Compaore AU - Jacques Simpore Y1 - 2024/09/06 PY - 2024 N1 - https://doi.org/10.11648/j.bmb.20240903.12 DO - 10.11648/j.bmb.20240903.12 T2 - Biochemistry and Molecular Biology JF - Biochemistry and Molecular Biology JO - Biochemistry and Molecular Biology SP - 53 EP - 62 PB - Science Publishing Group SN - 2575-5048 UR - https://doi.org/10.11648/j.bmb.20240903.12 AB - Background: Oxidative stress and chronic inflammation are crucial factors in the development of various diseases, such as hepatitis and cancer. In the case of hepatitis, persistent inflammation of the liver contributes to cellular damage and progression to more severe stages of the disease. Objective: The aim of this study is to evaluate the antioxidant and anti-inflammatory activity of a recipe, Hepatib tiben, traditionally used in the treatment of viral hepatitis B, and often associated with Momordica charantia in the treatment of liver cancer in Burkina Faso. Material and Methods: The recipe and associated plants were infused, macerated and the yields were evaluated and being freeze-dried. The extracts obtained were used to determine the total content of phenolic and flavonoid compounds by measuring the antioxidant activity through the FRAP, DPPH and ABTS methods and then the evaluation of the anti-inflammatory properties by inhibition of 15-LOX and COX 1 & 2. Results: The aqueous infusion of Hepatib tiben had the best yield, the highest content of phenolic compounds and flavonoids, an antioxidant activity comparable to that of Rutin, by the FRAP method, DPPH and ABTS method. But the best antioxidant activity by FRAP method was observed with the DCM fraction. It is on the other hand the hydroalcoholic extract which had the best anti-inflammatory activity by the inhibition of the 15-LOX. Both Aqueous and Hydroalcoholic Extracts inhibited COX 1 & 2. Momortica charantia had high phenolic content and significant antioxidant activity by FRAP, DPPH and ABTS methods. Conclusion: These observations suggest that the recipe of traditional medicinal plants used in Burkina Faso could be beneficial in the treatment of inflammatory conditions and oxidative stress. Further studies are needed to identify the active compounds responsible for these activities and to assess their safety and clinical effectiveness. VL - 9 IS - 3 ER -
Laboratory of Molecular Biology and Genetics (LABIOGENE), Department of Biochemistry and Microbiology, University Joseph KI-ZERBO, Ouagadougou, Burkina Faso; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso
Laboratory of Molecular Biology and Genetics (LABIOGENE), Department of Biochemistry and Microbiology, University Joseph KI-ZERBO, Ouagadougou, Burkina Faso; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso; Department of Life and Earth Sciences, Higher Normal School (ENS), Koudougou, Burkina Faso
Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso; Saint Camillus Hospital of Ouagadougou (HOSCO), Ouagadougou, Burkina Faso; Faculty of Health Sciences, University of Saint Thomas d’Aquin (USTA), Ouagadougou, Burkina Faso
Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso
Laboratory of Molecular Biology and Genetics (LABIOGENE), Department of Biochemistry and Microbiology, University Joseph KI-ZERBO, Ouagadougou, Burkina Faso; Pietro Annigoni Biomolecular Research Center (CERBA), Ouagadougou, Burkina Faso; Saint Camillus Hospital of Ouagadougou (HOSCO), Ouagadougou, Burkina Faso
