Volume 5, Issue 4, December 2020, Page: 50-59
Testing for the Association Between ACE DD (RS1799752) Polymorphism and the Metabolic Syndrome in Patients with Hypertension
Stanislav Alexandra Alina, Department of Biochemistry, Country Emergency Hospital, Clinical Laboratory Medical Analyzes, Giurgiu, Romania; Department of Genetics, Faculty of Biology, University of Bucharest, Bucharest, Romania
Received: Nov. 30, 2020;       Accepted: Dec. 7, 2020;       Published: Dec. 31, 2020
DOI: 10.11648/j.bmb.20200504.12      View  28      Downloads  27
Abstract
High blood pressure (HBP) is a complex multifactorial condition which has a polygenic predisposition. The angiotensin-converting enzyme (ACE) is one of the candidate genes for HBP, and the ACE ID polymorphism with DD genotype presents a high risk for myocardial infarction, obesity (OB), stroke, type 1 diabetes mellitus (DM1), type 2 diabetes mellitus (DM2), diabetic nephropathy. The purpose of the study is to identify the high risk of developing MS in ACE DD gene (RS1799752) on the basis of clinical data, biochemical laboratory investigations, genotyping and sequencing of ACE gene in patients with HBP, by using the mathematical algorithm ANOVA One Way as a linear model, with the help of the MDR, Graph Pad Prism and MATLAB software. This study includes 68 subjects, selected from Giurgiu County Emergency Hospital based on clinical data, biochemical investigations, RFLP-PCR genotyping and Advanced NGx sequencing of the ACE gene with the DD genotype to identify the increased risk of developing metabolic syndrome (MS) in patients with hypertension. The results was taken by using as a linear model the mathematical algorithm ANOVA One Way using the programs MDR, Graph Pad Prism and MATLAB. In conclusion the ACE DD polymorphism is significantly associated with MS in patients with hypertension.
Keywords
ACE Gene, DD Genotype, Metabolic Syndrome, Hypertension
To cite this article
Stanislav Alexandra Alina, Testing for the Association Between ACE DD (RS1799752) Polymorphism and the Metabolic Syndrome in Patients with Hypertension, Biochemistry and Molecular Biology. Vol. 5, No. 4, 2020, pp. 50-59. doi: 10.11648/j.bmb.20200504.12
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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