Volume 4, Issue 5, September 2019, Page: 74-79
Antagonism of Dexamethasone to Radiation Bystander Effect and Its Re-transmission
Zhan Hao, School of Clinical, Graduate School of Xuzhou Medical University, Xuzhou, China
Yao Ruoyu, School of Clinical, Graduate School of Xuzhou Medical University, Xuzhou, China
Zhang Xuguang, School of Clinical, Graduate School of Xuzhou Medical University, Xuzhou, China; Department of Radiotherapy, Xuzhou Cancer Hospital, Xuzhou, China
Received: Oct. 8, 2019;       Accepted: Nov. 8, 2019;       Published: Nov. 15, 2019
DOI: 10.11648/j.bmb.20190405.12      View  37      Downloads  8
Abstract
Background: In clinical radiotherapy, in addition to the symptoms of radiation damage in the irradiated area, normal tissues can produce damage other than direct irradiation due to bystander effects. We often use dexamethasone to relieve symptoms, thereby protecting the surrounding normal tissues, and may also protect the tissues outside the target area. Objectives: To observe the antagonism of dexamethasone on radiation bystander effect and its Re-transmission. Materials and methods: After 6MV X-ray irradiation of rabbit, the plasma, the first generation conditioned medium, was prepared to treat rabbit lymphocyte, cultured for 24 hours, 24 hours later, lymphocytes were collected, and the second generation conditioned medium was prepared with the lymphocyte secretion to treat new rabbit lymphocyte, and the apoptotic rate of effecter lymphocyte was detected. Dexamethasone was used as a parallel treatment control in all experimental groups. Results: The first and second generations of conditioned medium can stimulate lymphocyte apoptosis. Dexamethasone could reduce the apoptotic level of rabbit lymphocytes treated with the first and second generation bystander conditioned medium from 21.087% to 14.957%, 28.695% to 20.205%, respectively. Conclusion: Under certain conditions, dexamethasone can antagonize the injury of lymphocyte by radiation bystander effect, and can also antagonize the re-transmission of radiation bystander effect.
Keywords
Radiation Bystander Effect, Re-transmission, Dexamethasone
To cite this article
Zhan Hao, Yao Ruoyu, Zhang Xuguang, Antagonism of Dexamethasone to Radiation Bystander Effect and Its Re-transmission, Biochemistry and Molecular Biology. Vol. 4, No. 5, 2019, pp. 74-79. doi: 10.11648/j.bmb.20190405.12
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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