Volume 4, Issue 3, May 2019, Page: 35-41
Antineoplastic, Bio-Chemical, Cytotoxic and Antimicrobial Investigation on Synthesized Schiff Base Co(II) Ion Complex
Kudrat-E-Zahan, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
Saddam Hossain, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
M. M. Haque, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
Laila Arjuman Banu, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
M. A. Matin, Department of Materials Science and Engineering, University of Rajshahi, Rajshahi, Bangladesh
Nur Amin Bitu, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
Ahsan Habib, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
Ashrafuzzaman, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
Nayon Uddin, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
M. S. Islam, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
Received: Mar. 21, 2019;       Accepted: May 31, 2019;       Published: Aug. 6, 2019
DOI: 10.11648/j.bmb.20190403.11      View  131      Downloads  44
Abstract
Antibiotic resistance has been growing at an alarming rate and consequently the activity of antibiotics has dropped dramatically day by day. Metal complex [Co (SB) (SCN)] (where, SB = 2-[(6-Amino-hexylimino)-methyl] phenol) have been reported for the purpose of searching new antimicrobial agents. The Schiff base and it’s transition metal complex was characterized by means of several physiochemical and spectroscopic methods. Several biomedical toxicological properties of the complex has been determined by monitoring the parameters cell growth inhibition, survival time of tumour mice, time-body relation, causing of intraperitoneal cells and macrophages, alkaline phosphatase activity, haematological effect and biopsy of tumour. The synthesized Schiff base Co (II) complex was found to have anticancer and cytotoxic function.
Keywords
Transition Metal Complex, Antineoplastic, Bio-Chemical, Cytotoxic and Antimicrobial Studies
To cite this article
Kudrat-E-Zahan, Saddam Hossain, M. M. Haque, Laila Arjuman Banu, M. A. Matin, Nur Amin Bitu, Ahsan Habib, Ashrafuzzaman, Nayon Uddin, M. S. Islam, Antineoplastic, Bio-Chemical, Cytotoxic and Antimicrobial Investigation on Synthesized Schiff Base Co(II) Ion Complex, Biochemistry and Molecular Biology. Vol. 4, No. 3, 2019, pp. 35-41. doi: 10.11648/j.bmb.20190403.11
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
Thompson KH, Orvig C., Metal complexes in medicinal chemistry: new vistas and challenges in drug design. Dalton Trans. 2006, 6: 761–764.
[2]
Jung Y, Lippard SJ. Direct cellular responses to platinum-induced DNA damage. Chem Rev., 2007, 107: 1387–1407.
[3]
Hambley TW. Developing new metal-based therapeutics: challenges and opportunities. Dalton Trans. 2007, 43: 4929–4937.
[4]
Orvig C, Abrams MJ, Medicinal inorganic chemistry: introduction. Chem Rev. 1999, 99: 2201– 2203.
[5]
Guo Z, Sadler PJ., Metals in Medicine. Angew Chem Int Ed. 1999, 38: 1512–1531.
[6]
A. Faizul, S. Satendra, L. K. Sukhbir. P. Om. Synthesis of Schiff bases of naphtha [1, 2-d] thiazol-2-amine and metal complexes of 2- (2′-hydroxy) benzyli deneamino naphtha thiazole as potential antimicrobial agents. J. Zhejiang Univ Sci. 2007, 8 (6): 446–452.
[7]
G. U. Maass, B. Koenig, U. Leser, B. Mueller, R. Goody, B. Pfatt, Viral resistance to the thiazole isoindolinones, a new class NNRTI of HIV-1 reverse transcriptase. Antimicrob Agents Chemother. 37 (12): 1993, 2612–2617.
[8]
Geronikaki, D. Hadjipavlou-Litina, M. Amourgianou. Novel thiazolyl, thiazolinyl and benzothiazolyl, Schiff bases: a possible lipoxygenase’s inhibitors and anti-inflammatory agents. IL Farmaco. 2003, 58 (7): 489–495.
[9]
M. Malathy, R. Rajavel, Copper (II) complexes as in vitro anticancer agents against human breast cancer mcf-7 cell line: a review. European J. of Biomed. and Pharmaceutical sciences. 2015, 2 (3): 177-200.
[10]
C. Jayabalakrishnan, R. Karvembu, K. Natarajan, Catalytic and antimicrobial activities of new ruthenium (II) unsymmetrical Schiff base complexes. Trans. Met. Chem. 2002, 27: 790–794.
[11]
R. Prabhakaran, A. Geetha, M. Thilagavathi, R. Karvembu, V. Krishnan, H. Bertagnolli, K. Natarajan, Synthesis, characterization, EXAFS investigation and antibacterial activities of new Ru (III) complexes containing tetradentate Schiff base complexes. J. Inorg. Biochem. 2004, 98: 2131–2140.
[12]
K. P. Balasubramanian, R. Karvembu, R. Prabhakaran, V. Chinnusamy, K. Natarajan. Synthesis, spectral, catalytic and antimicrobial studies of PPh3/AsPh3 complexes of Ru (III) with dibasic tridentate O, N, S donor ligands. Spectrochim. Acta Part A. 2007, 68: 50–54.
[13]
S. A. Sadeek, M. S. Refat, Preparation and Characterization of Tin (II) Complexes with Isomeric Series of Schiff Bases as Ligands. J. Korean Chem. Soc., 2006, 50 (2): 107–115.
[14]
M. M. Haque, Md. Kudrat-E-Zahan, Laila Arjuman Banu, Md. Shariful Islam and M. S. Islam, synthesis and Characterization with Antineoplastic, Bio-Chemical, Cytotoxic and Antimicrobial studies of schiff base Cu (II) ion Complexes. Bioinorganic Chemistry and Applications, 2015, Article ID 923087, p. 7.
[15]
W. J. Geary, The use of conductivity measurements in organic solvents for the characterisation of coordination compounds. Coordination Chemistry Reviews, 1971, 7 (1): 81–122.
[16]
Md. Saddam Hossain, Md. Ashraful Islam, C. M. Zakaria, M. M. Haque, Md. Abdul Mannan, Md. Kudrat-E-Zahan, Synthesis, Spectral and Thermal Characterization with Antimicrobial Studies on Mn (II), Fe (II), Co (II) and Sn (II) Complexes of Tridentate N, O Coordinating Novel Schiff Base Ligand. J. Chem. Bio. Phy. Sci, 2016, 7 (4): 041-052.
[17]
Md. Saddam Hossain, C. M. Zakaria, M. K. Zahan, Synthesis and Characterization with Antimicrobial Activity studies on some Transition metal complexes of N, O donor novel Schiff base ligand. J. Sci. Res. 2017, 9 (2): 209-218.
[18]
Md. Shiraj-U-Ddaula, Md. Anarul Islam, Shejuty aktar, Md. Khairul Islam, Md. Abdul Alim Al-Bari, Md. Masuqul Haque and Md. Kudrat-E-Zahan, Synthesis, Characterization and Antimicrobial Activity of Cd (II), Ni (II), Co (II) and Zr (IV) Metal Complexes of Schiff Base Ligand Derived from Diethylenetriamine and Isatin. Asian J. Research Chem. 2014, 7 (7): 619-621.
[19]
Ahmed Jasim M. Al-Karawi, Synthesis and characterization of a new N2S2 Schiff base ligand and its complexes with nickel (II), copper (II) and cadmium (II) including the kinetics of complex formation. Transition Met Chem, 2009, 34: 891–897.
[20]
Md. Saddam Hossain, C. M. Zakaria, Md. Kudrat-E-Zahan, Synthesis, Spectral and Thermal Characterization of novel Cu (II) Complexes with Two New Schiff Base Ligand towards Potential Biological Application. Der Chemica Sinica, 2017, 8 (3): 380-392.
[21]
Md. Saddam Hossain, Shudeepta Sarker, A. S. M. Elias Shaheed, Md. Mamun Hossain, Abdul Alim-Al-Bari, Md. Rabiul Karim, C. M. Zakaria, Md. Kudrat-E-Zahan, Thermal and Spectral Characterization of Cr (III), Co (II) and Cd (II) Metal Complexes Containing Bis-Imine Novel Schiff Base Ligand Towards Potential Biological Application. Chemical and Biomolecular Engineering. 2017, 2 (1): 41-50.
[22]
Xinde Zhu, Chenggang Wang, Zhiping Lu and Yuanlin Dang, Synthesis, characterization and biological activity of the Schiff base derived from 3, 4-dihydroxybenzaldehyde and thiosemicarbazide, and its complexes with nickel (II) and iron (II). Transition Met. Chem. 1997, 22: 9–13.
[23]
Wilfredo Hernández, Juan Paz, Lothar Hennig, Joachim Sieler, Steffen Blaurock, and Lothar Beyer, Synthesis and Characterization of New Palladium (II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines. Bioinorganic Chemistry and Applications, 2013, Article ID 524701, p. 12,
[24]
B. P. Lever (1984) “Inorganic Electronic Spectroscopy” Elsevier, Amsterdam.
[25]
Md. Kudrat-E-Zahan and M. S. Islam, Characterization, and antimicrobial activity of complexes of Cu (II), Ni (II), Zn (II), Pb (II), Co (II), Mn (II), and U (VI) containing bidentate Schiff base of [S-methyl-3-(4-methoxybenzylidine)dithiocarbazate],” Russian Journal of General Chemistry, 2015, 85 (4): 979– 983.
[26]
Ikechukwu P. Ejidike and Peter A. Ajibade, Synthesis, Characterization and Biological Studies of Metal (II) Complexes of (3E)-3-[(2-{(E)-[1-(2, 4-Dihydroxyphenyl) ethylidene] amino}ethyl) imino]-1-phenylbutan-1-one Schiff Base. Molecules, 2015, 20: 9788-9802.
Browse journals by subject